ITGAL CLIA Kit for Human(Homo sapiens) | EIAab.comITGAL CLIA Kit for Human(Homo sapiens)

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Index > Protein center > ITGAL(Gene name) > Human

ITGAL (Gene name),

Integrin alpha-L (Protein name ), ITAL_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ITGAL(CD11A);

Protein name:

Integrin alpha-L;

Alternative:

Leukocyte adhesion glycoprotein LFA-1 alpha chain(LFA-1A);CD11 antigen-like family member A;Leukocyte function-associated molecule 1 alpha chain;

CD:

CD11a;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.

Function:

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1170

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1170:

DPGCLKPLHE | KDSESGGGKD |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000349252

String:

P20701

MIM:

153370

UniGene:

Hs.174103

KEGG:

hsa:3683

SMR:

P20701

Pfam:

PF01839

Uniprot:

P20701

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ELISA Kit for Human Integrin alpha-L

Cat.:

E1572h

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Manual:

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Packing:

96T

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ELISA Kit for Human Integrin alpha-L

Cat.:

E1572b

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MSDS:

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Packing:

96T

ELISA Kit for Human Integrin alpha-L

Cat.:

E1572m

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MSDS:

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Packing:

96T

CLIA Kit for Human Integrin alpha-L

Cat.:

U1572m

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MSDS:

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Packing:

96T

CLIA Kit for Human Integrin alpha-L

Cat.:

U1572b

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Integrin alpha-L

Cat.:

U1572h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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Polyclonal Antibody for Human Integrin alpha-L

Cat.:

P1572Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Integrin alpha-L

Cat.:

P1572Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Integrin alpha-L

Protein for Human Integrin alpha-L

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily."
Larson R.S. , Corbi A.L. , Berman L. , Springer T.
J. Cell Biol.108:703-712(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;VARIANT TRP-214
2.

NIEHS SNPs program
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-144; TRP-214; LYS-746 AND THR-791
3.

"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
Loftus B.J. , Kim U.-J. , Sneddon V.P. , Kalush F. , Brandon R. , Fuhrmann J. , Mason T. , Crosby M.L. , Barnstead M. , Cronin L. , Mays A.D. , Cao Y. , Xu R.X. , Kang H.-L. , Mitchell S. , Eichler E.E. , Harris P.C. , Venter J.C. , more...
Genomics60:295-308(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2);VARIANT TRP-214
4.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Lymph.
7.

"Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene."
Shelley C.S. , Farokhzad O.C. , Arnaout M.A.
Proc. Natl. Acad. Sci. U.S.A.90:5364-5368(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20
8.

"Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter."
Nueda A. , Lopez-Cabrera M. , Vara A. , Corbi A.L.
J. Biol. Chem.268:19305-19311(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20
9.

"Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter."
Cornwell R.D. , Gollahon K.A. , Hickstein D.D.
Proc. Natl. Acad. Sci. U.S.A.90:4221-4225(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20
10.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-188
tissue: Leukemic T-cell.
11.

"Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin."
Qu A. , Leahy D.J.
Proc. Natl. Acad. Sci. U.S.A.92:10277-10281(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 153-335;SEQUENCE REVISION TO 214
12.

"The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin."
Qu A. , Leahy D.J.
Structure4:931-942(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 153-335
13.

"Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain."
Kallen J. , Welzenbach K. , Ramage P. , Geyl D. , Kriwacki R. , Legge G. , Cottens S. , Weitz-Schmidt G. , Hommel U.
J. Mol. Biol.292:1-9(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 153-334
14.

"Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation."
Shimaoka M. , Xiao T. , Liu J.H. , Yang Y. , Dong Y. , Jun C.D. , McCormack A. , Zhang R. , Joachimiak A. , Takagi J. , Wang J.H. , Springer T.A.
Cell112:99-111(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 155-331 IN COMPLEX WITH ICAM1

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